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KMID : 0941820030130020055
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Korean Journal of Clinical Pharmacy
2003 Volume.13 No. 2 p.55 ~ p.58
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Pharmacokinetics of Astromicin Following a Single Intravenous Infusion in Healthy Korean Subjects
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Bok Hae-Sook
Choi Kyung-Eob
Kim Yeon-Hwa
Peck Kyong-Ran
Song Jae-Hoon
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Abstract
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Astromicin is an aminoglycoside antiviotic that is structually different from conventional aminoglycosides. Astromicin has been shown to be active against aerobic Gram-negative bacilli. The pharmacokinetics of astromicin were determined in 12 healthy volunteers (65.5pm5.23;kg of body weight) following a 30-min continuous intravenous infusion at a dose of 200 mg. The plasma and urine samples were collected up to 24 h and drug concentrations were measured by a bioassay using Bacillus subtilis. Pharmacokinetic parameters were calculated by fitting individual concentration-time curve to a one-exponential decay model. The plasma levels were 16.9pm1.68;and;1.05pm0.346l{mu}g/ml at 0 h and 8 h after the infusion, respectively. The elimination half-life of astromicin was 1.86pm0.360;h The volume of distribution was 0.182pm0.0164;L/kg, and the total body clearance was 5.25pm1.74;L/h. These pharmacokinetic parameters were similar to these of gentamicin, tobramycin, and amikacin. Therefore, it is recommended that therapeutic drug monitoring of astromicin could be conducted in a similar fashion as the other aminoglycosides.
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KEYWORD
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Aminoglycosides, Astromicin, Pharmacokinetics, Intravenous infusion, Healthy Koreans
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